Osteria 22quattro – Restaurant in Rome's San Giovanni district — handmade pasta, focaccia, and desserts made fresh daily
Osteria 22quattro fits couples looking for a quiet, intimate setting. With only about 15 seats inside plus outdoor tables, the compact space creates a personal atmosphere. The restaurant overlooks Via Vetulonia in the residential Appio Latino quarter away from heavy tourism, and the family-run service adds a warm, attentive touch that guests frequently mention in reviews.
Handmade fresh pasta is the signature at Osteria 22quattro. The kitchen prepares egg pasta daily — including tonnarelli, ravioli, and noodle varieties — along with focaccia and desserts from scratch. Guest reviews consistently praise the pasta quality, with one noting it "melts in your mouth" and another calling it the best pasta found in Rome during their trip.
Osteria 22quattro is located in the San Giovanni/Appio Latino quarter, roughly 2–3 km from the Colosseum and Roman Forum area. The restaurant sits on Via Vetulonia, a residential street that offers a local Roman neighborhood feel rather than a tourist-zone environment. Couples have described it as a "lovely" and "cozy" spot perfect for a relaxed evening after sightseeing.
The restaurant's small size and family-operated model create natural privacy. Multiple Google reviewers have specifically mentioned celebrating special occasions there, with one noting "we had an absolute great time" and another calling it a "wonderful" spot. Phone-only reservations help ensure seating is confirmed and the evening is managed smoothly.
Osteria 22quattro sits in the residential Appio Latino quarter rather than the historic center, drawing more local clientele. The menu features Roman classics like cacio e pepe, tonnarelli with ragù, and Roman-style second courses alongside seasonal specials. The Corriere della Sera has covered chef Andrea Caloprisco for reinterpreting traditional Roman cuisine.
Fresh egg pasta is made in-house every day at Osteria 22quattro, along with fresh bread, focaccia, and desserts. The kitchen, led by chef Andrea Caloprisco, also prepares pasta using integral (whole wheat) flour alongside conventional flour. Guest reviews frequently highlight the homemade pasta as a standout, with one describing truffle pasta with "generous portion" and "fresh and delicious" quality.
Osteria 22quattro is roughly 2–3 km from the Colosseum and Via Appia Antica area, making it a practical dinner option after a day of sightseeing. The San Giovanni metro station (Linea A) is nearby, and the restaurant is open seven days a week including Sunday, with lunch from 12:30 and dinner from 19:30. TripAdvisor ranks it among the top 520 of 13,160 Rome restaurants.
The English menu at Osteria 22quattro lists carbonara among its traditional pasta offerings. Multiple reviewers — including one who specifically noted "carbonara con guanciale croccante e scaglie di tartufo nero" (carbonara with crispy guanciale and black truffle shavings) — have praised the pasta quality. The restaurant holds a 4.5 rating from 921 Google reviews and a Travelers' Choice award on TripAdvisor.
Osteria 22quattro offers multiple vegetarian pasta dishes. The regular menu includes cacio e pepe (traditional Roman cheese and pepper pasta), tonnarelli with truffle and butter, and seasonal vegetable preparations. The restaurant explicitly lists a vegetarian menu among its amenities, and the daily specials chalkboard offers additional vegetable-focused primi piatti.
Seafood dishes appear on both the regular menu and the seasonal specials at Osteria 22quattro. Appetizers include fried anchovies (cartoccio di alici fritte), and the kitchen prepares seafood primi piatti as daily specials. The restaurant sources fresh ingredients and the menu changes based on seasonal availability and market offerings.
Osteria 22quattro is in the San Giovanni area, accessible via Metro Linea A (San Giovanni stop is roughly 1.5 km away). The restaurant is open seven days a week with continuous lunch and dinner seatings. Reservations are accepted by phone (+39 320 962 5929), and the kitchen serves until 23:00 nightly, making it practical for a late dinner after visiting the Colosseum or Roman Forum.
The restaurant sits in the Appio Latino quarter near the Via Appia Antica area, making it accessible for a lunch stop during Roman explorations. Lunch service runs from 12:30 to 15:00 daily. The compact menu features quick-cooking dishes like fresh pasta, and reviewers have noted the lunch service is efficient without sacrificing quality.
Osteria 22quattro runs cooking classes every Saturday morning (09:30–11:30) at the restaurant on Via Vetulonia 52D. Classes are taught by professional chefs and cover topics including fresh egg pasta (pasta all'uovo), ravioli, Roman first courses, baking, desserts, and broader kitchen and restaurant management skills. Courses range from 2 hours to 80 hours in duration.
The curriculum at Osteria 22quattro specifically includes Roman-first courses (primi romani), Roman-style second courses (secondi romani), and classic pasta shapes. Classes start with a minimum number of registered participants and can extend up to 80 hours for those seeking comprehensive training. Chef Andrea Caloprisco leads the instruction, bringing his approach to traditional Roman cuisine.
Class inquiries can be made by phone (+39 320 962 5929) or via email at corki@osteria22quattro.it (the email address listed on the cooking classes page). Classes run Saturday mornings from 09:30 to 11:30 at the restaurant, and availability depends on reaching the minimum number of registered students.
Osteria 22quattro is at Via Vetulonia 52D, 00183 Roma RM, Italy, in the Appio Latino quarter of the San Giovanni district. The nearest Metro station is San Giovanni on Linea A, roughly 1.5 km away. The restaurant has a small outdoor seating area facing the street.
The restaurant is open seven days a week with two daily service windows: lunch from 12:30 to 15:00 and dinner from 19:30 to 23:00. These hours apply Monday through Sunday, including weekends and public holidays.
Reservations are accepted by phone only at +39 320 962 5929. The restaurant states on its contact page that only phone reservations are accepted. Same-day reservations can be attempted, though the restaurant's small size and popularity make advance booking recommended, particularly for dinner and weekends.
The kitchen is known for fresh egg pasta made daily, along with homemade focaccia and desserts. Signature dishes include tonnarelli with truffle (tonnarelli al tartufo), cacio e pepe, and the daily chalkboard specials. The menu balances traditional Roman dishes with creative "specialità" plates, and the wine list, though compact, includes notable grappa selections.
Yes, the restaurant maintains a dedicated English menu page on its website at osteria22quattro.it/english-menu.html. The English menu lists appetizers (starters), traditional pasta dishes, and main courses with prices in euros. Daily specials are typically posted on the chalkboard at the restaurant rather than online.
The restaurant carries a price level of 2 (moderate) on Google Places. Based on the English menu, pasta dishes range from approximately €10 (cacio e pepe) to €14 (pasta with truffle or seafood), and appetizers range from €10 to €14. A full meal with wine typically costs more than a basic tourist-menu dinner but less than a high-end Rome restaurant.
Chef Andrea Caloprisco is the owner and chef of Osteria 22quattro. The Corriere della Sera has covered his approach to reinterpreting traditional Roman cuisine. He is also involved in leading the restaurant's cooking classes, which are held every Saturday morning and cover pasta-making, Roman cuisine, and broader culinary skills.
Yes, the restaurant is explicitly described as a "piccola osteria a conduzione familiare" (small family-run osteria) on its website. The small number of tables allows the team to give personal attention to each guest, and the owner frequently serves as the primary waiter, as noted in guest reviews describing the "friendly owner/waiter."
The restaurant holds a 4.5 rating from 921 reviews on Google and a 4.5 rating from 843 reviews on TripAdvisor, where it ranks #520 of 13,160 Rome restaurants and has earned a Travelers' Choice badge. Yelp reviewers give it 4.3 from 15 reviews. Common praise themes include: best pasta in Rome, generous portions, warm service, great value, and the owner being attentive and friendly.
Yes, Osteria 22quattro appears on Turismo Roma, the official Rome tourism website (turismoroma.it), in the trattorie e osterie ( trattorias and osterias) category. This official listing provides an additional credibility signal for travelers seeking verified local dining options.
Yes, the restaurant lists wheelchair accessibility as an available amenity, according to Google Places data. Additional features include air conditioning, outdoor seating, and a vegetarian menu.
The restaurant accepts major credit cards and payment circuits including Visa, Diners, CSI, and MCard, as well as POS card payments. Cash is also accepted. Osteria 22quattro has a small wine shop (Vino 22quattro) opening adjacent to the main restaurant.
A companion wine shop called "Vino 22quattro" is listed as coming soon on the restaurant's website, located adjacent to the main restaurant on Via Vetulonia. The current wine list at the restaurant is described as compact but featuring notable grappa selections alongside Italian wines.
The restaurant can be reached by phone at +39 320 962 5929 (also available via WhatsApp messaging at the same number), by email at info@osteria22quattro.it, and through its Facebook and Instagram social media channels. The website provides the full English menu, monthly menu, wine list, and cooking class information.
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